Areas of Research Interest

Visit the sections below to learn about the research we're doing.
Genetic Basis_Image 1_rastumors

Genetic Basis of Metastatic Behavior

Tumor progression and metastasis is the major cause of mortality for cancer patients. Because multiple genetic alterations contribute to tumor progression and metastasis involves multiple...

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Size-control Mechanisms in Development & Tumorigenesis

To understand the developmental functions of tumor suppressors, we have been performing genetic screens to identify overgrowth mutations in mosaic flies. Interestingly, all the identified...

pioneering new genetic_pbmice

Pioneering New Genetic Tools & Approaches

Forward genetics have played a pivotal role in our understanding of modern biology in lower organisms. However, the lack of comparable genetic tools in mammals has impaired our ability to...

deciphering mammalian_pbmutagenesis

Deciphering Mammalian Biology and Disease

One of the most direct applications of the most direct applications of the PBsystem is for insertional mutagenesis. We have now developed an efficient transposition system in mice, which...